Degree

• 理学修士（東京大学）
• 博士（医学）（東京女子医科大学）

Research History

Education

Awards

Others

Papers

• Eccentric contraction increases hydrogen peroxide levels and alters gene expression through Nox2 in skeletal muscle of male mice（2024-09-01） [DOI] [Othres link]
• In vivo cytosolic H2O2 changes and Ca2+ homeostasis in mouse skeletal muscle.（2023-10-30） [DOI] [PubMed]
• Ryanodine receptors mediate high intracellular Ca²⁺ and some myocyte damage following eccentric contractions in rat fast twitch skeletal muscle（2022-01-01） [DOI] [PubMed]
• Dual-FRET imaging of IP₃ and Ca²⁺ revealed Ca²⁺-induced IP₃ production maintains long lasting Ca²⁺ oscillations in fertilized mouse eggs（2019-03-18）
• In vitro Ca²⁺ dynamics induced by Ca²⁺ injection in individual rat skeletal muscle fibers.（2017-03-13） [DOI] [PubMed] [PubMed Central]
• Calcium Signaling in Mammalian Eggs at Fertilization（2016） [DOI] [Web of Scientce]
• Ca2+ influx-dependent refilling of intracellular Ca2+ stores determines the frequency of Ca2+ oscillations in fertilized mouse eggs（2013-01） [DOI] [Web of Scientce]
• Characterization of store-operated Ca²⁺ entry in mouse eggs（2011）
• FUNCTIONAL ROLE OF CRAC CHANNELS IN THE GENERATION AND MAINTENANCE OF Ca2+ OSCILLATIONS IN MAMMALIAN EGGS（2009） [Web of Scientce]
• CHARACTERIZATION OF Ca2+ INFLUX PATHWAY ACTIVATED DURING Ca2+ OSCILLATIONS IN MOUSE EGGS（2009） [Web of Scientce]
• Measurement of intracellular IP3 during Ca2+ oscillations in mouse eggs with GFP-based FRET probe（2006-06） [DOI] [Web of Scientce]
• Measurement of IP₃ in mouse eggs with FRET-based probe（2006）
• The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase C xi（2005-06） [Web of Scientce]
• Nuclear translocation of phospholipase C-zeta, an egg-activating factor, during early embryonic development（2005-05） [DOI] [Web of Scientce]
• Ca2+ oscillation-inducing phospholipase C zeta expressed in mouse eggs is accumulated to the pronucleus during egg activation（2004-04） [DOI] [Web of Scientce]
• Blind spectral decomposition of single-cell fluorescence by parallel factor analysis（2004-03） [Web of Scientce]
• PLCζ expressed in the mouse egg induces Ca²⁺ oscillations and is accumulated into the pronucleus（2004）
• Characterization of PLC-zeta: Ca²⁺ oscillation-inducing sperm factor（2004）
• 広波長域２次元蛍光スペクトル顕微測光にによる多因子分離解析法の細胞生理学的応用（2004）
• 広波長域２次元蛍光スペクトル顕微測光に基づく多因子同時解析システムの構築（2003）
• 可視光励起プローブによる細胞内カルシウムのレシオメトリック測定（2002）
• Novel green fluorescent protein-based ratiometric indicators for monitoring pH in defined intracellular microdomains（2001-11） [Web of Scientce]
• Analysis of Mn2+/Ca2+ influx and release during Ca2+ oscillations in mouse eggs injected with sperm extract（2001-05） [DOI] [Web of Scientce]
• IP₃誘発性Ca遊離に伴う小胞体膜電位変化の光学的解析（2001）
• Ca2+/Mn2+ dynamics during Ca2+ oscillations in mouse eggs injected with sperm extract（2000-12） [Web of Scientce]
• Spatiotemporal analysis of Ca2+ waves in relation to the sperm entry site and animal-vegetal axis during Ca2+ oscillations in fertilized mouse eggs（2000-02） [Web of Scientce]
• Spatiotemporal analysis of Ca2+ waves in relation to the sperm entry site and animal-vegetal axis during Ca2+ oscillations in fertilized mouse eggs（2000-02） [Web of Scientce]
• Numerical simulation of Mn²⁺ quenching of fura-2 during Ca²⁺ oscillations in mouse eggs.（2000）
• Dual-wavelength ratiometric fluorescence measurement of endolasmic reticulum membrane potential using voltage-sensitive dyes（2000）
• Effect of FK506 on ATP-induced intracellular calcium oscillations in cow tracheal epithelium（1999-06） [Web of Scientce]
• Effect of FK506 on ATP-induced intracellular calcium oscillations in cow tracheal epithelium（1999-06） [Web of Scientce]
• Spatiotemporal characterization of intracellular Ca2+ rise during the acrosome reaction of mammalian spermatozoa induced by zona pellucida（1999-04） [Web of Scientce]
• Spatiotemporal characterization of intracellular Ca2+ rise during the acrosome reaction of mammalian spermatozoa induced by zona pellucida（1999-04） [Web of Scientce]
• Sperm-induced signaling in mouse eggs.（1999）
• Erythromycin inhibits ATP-Induced intracellular calcium responses in bovine tracheal epithelial cells（1998-11） [Web of Scientce]
• Erythromycin inhibits ATP-Induced intracellular calcium responses in bovine tracheal epithelial cells（1998-11） [Web of Scientce]
• Sperm-induced local [Ca2+](i) rise separated from the Ca2+ wave in sea urchin eggs in the presence of a gamete fusion inhibitor, jaspisin（1998-01） [Web of Scientce]
• Sperm-induced local [Ca2+](i) rise separated from the Ca2+ wave in sea urchin eggs in the presence of a gamete fusion inhibitor, jaspisin（1998-01） [Web of Scientce]
• High-resolution analysis of Ca²⁺ rise in hamster spermatozoa induced by solubilized zona pellucida（1998）
• マウス卵細胞室内精子注入により誘発される細胞内カルシウム増加の解析（1998）
• Spatiotemporal dynamics of intracellular calcium in the mouse egg injected with a spermatozoon（1997-12） [Web of Scientce]
• Spatiotemporal dynamics of intracellular calcium in the mouse egg injected with a spermatozoon（1997-12） [Web of Scientce]
• Role of inositol trisphosphate and tetrakisphosphate in Ca²⁺ release and Ca²⁺ influx in hamster eggs（1997）
• Spatiotemporal analysis of calcium dynamics in hamster spermatozoa during acrosome reaction observed with confocal microscopy（1997）
• 共焦点レーザー走査顕微鏡を用いたハムスター精子細胞内カルシウム増加の解析（1997）
• Spatiotemporal analysis of calcium dynamics in the nucleus of hamster oocytes（1996-07） [Web of Scientce]
• Spatiotemporal analysis of calcium dynamics in the nucleus of hamster oocytes（1996-07） [Web of Scientce]
• ハムスター卵核内カルシウム動態の解析（1996）
• DEVELOPMENTAL-CHANGES IN THE DISTRIBUTION OF THE ENDOPLASMIC-RETICULUM AND INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS AND THE SPATIAL PATTERN OF CA2+ RELEASE DURING MATURATION OF HAMSTER OOCYTES（1995-08） [Web of Scientce]
• DEVELOPMENTAL-CHANGES IN THE DISTRIBUTION OF THE ENDOPLASMIC-RETICULUM AND INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS AND THE SPATIAL PATTERN OF CA2+ RELEASE DURING MATURATION OF HAMSTER OOCYTES（1995-08） [Web of Scientce]
• EVIDENCE FOR INOSITOL TETRAKISPHOSPHATE-ACTIVATED CA2+ INFLUX PATHWAY REFILLING INOSITOL TRISPHOSPHATE-SENSITIVE CA2+ STORES IN HAMSTER EGGS（1995-01） [Web of Scientce]
• EVIDENCE FOR INOSITOL TETRAKISPHOSPHATE-ACTIVATED CA2+ INFLUX PATHWAY REFILLING INOSITOL TRISPHOSPHATE-SENSITIVE CA2+ STORES IN HAMSTER EGGS（1995-01） [Web of Scientce]
• ハムスター未成熟卵でのIP₃依存性カルシウム遊離機構の局在とその卵成熟に伴う変化（1995）
• Sperm-egg fusion in the sea urchin is blocked in Mg2+-free seawater（1994） [DOI] [PubMed]
• 精子ー卵相互作用のシグナル伝達メカニズム（1994） [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link]
• 共焦点レーザー顕微鏡 その原理と応用（1994） [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link]
• 細胞内Ca²⁺を見る 「電子顕微鏡基礎技術と応用1994～物質のナノ局在解析～」（1994）
• Sperm-egg fusion in the sea urchin is blocked in Mg2+-free seawater（1994） [DOI] [PubMed]
• ハムスター卵受精時のカルシウム動態の解析（1994）
• ESSENTIAL ROLE OF THE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR/CA2+ RELEASE CHANNEL IN CA2+ WAVES AND CA2+ OSCILLATIONS AT FERTILIZATION OF MAMMALIAN EGGS（1993-07） [Web of Scientce]
• DEVELOPMENT OF INOSITOL TRISPHOSPHATE-INDUCED CALCIUM RELEASE MECHANISM DURING MATURATION OF HAMSTER OOCYTES（1993-03） [Web of Scientce]
• DEVELOPMENT OF INOSITOL TRISPHOSPHATE-INDUCED CALCIUM RELEASE MECHANISM DURING MATURATION OF HAMSTER OOCYTES（1993-03） [Web of Scientce]
• CA2+-INDUCED CA2+ RELEASE MEDIATED BY THE IP3 RECEPTOR IS RESPONSIBLE FOR CA2+ WAVES AND CA2+ OSCILLATIONS AT FERTILIZATION OF MAMMALIAN EGGS（1993） [Web of Scientce]
• CA2+-INDUCED CA2+ RELEASE MEDIATED BY THE IP3 RECEPTOR IS RESPONSIBLE FOR CA2+ WAVES AND CA2+ OSCILLATIONS AT FERTILIZATION OF MAMMALIAN EGGS（1993） [Web of Scientce]
• Regulation of calcium influx pathway by inositol 1,3,4,5-tetrakisphosphate in hamster eggs（1993）
• Confocal Ca²⁺ imaging of hamster oocytes following fertilization or IP₃ injection（1993）
• ANTIBODY TO THE INOSITOL TRISPHOSPHATE RECEPTOR BLOCKS THIMEROSAL-ENHANCED CA2+-INDUCED CA2+ RELEASE AND CA2+ OSCILLATIONS IN HAMSTER EGGS（1992-09） [Web of Scientce]
• EVIDENCE THAT METALLOENDOPROTEASES ARE INVOLVED IN GAMETE FUSION OF CIONA-INTESTINALIS, ASCIDIA（1992-09） [Web of Scientce]
• ANTIBODY TO THE INOSITOL TRISPHOSPHATE RECEPTOR BLOCKS THIMEROSAL-ENHANCED CA2+-INDUCED CA2+ RELEASE AND CA2+ OSCILLATIONS IN HAMSTER EGGS（1992-09） [Web of Scientce]
• EVIDENCE THAT METALLOENDOPROTEASES ARE INVOLVED IN GAMETE FUSION OF CIONA-INTESTINALIS, ASCIDIA（1992-09） [Web of Scientce]
• BLOCK OF CA2+ WAVE AND CA2+ OSCILLATION BY ANTIBODY TO THE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN FERTILIZED HAMSTER EGGS（1992-07） [Web of Scientce]
• Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs（1992） [DOI] [PubMed]

Misc

• In vivo環境下におけるマウス骨格筋ミトコンドリア内Ca²⁺動態の可視化—In vivo visualization of mitochondrial Ca²⁺ dynamics in mouse skeletal muscle during contractions（2024-01） [CiNii Books] [CiNii Research] [Othres link] [Othres link]
• In vivo環境下におけるマウス骨格筋ミトコンドリア内Ca²⁺動態の可視化—In vivo visualization of mitochondrial Ca²⁺ dynamics in mouse skeletal muscle during contractions（2023-04） [CiNii Books] [CiNii Research] [Othres link] [Othres link]
• 哺乳類卵活性化精子蛋白質候補ホスホリパーゼCゼータ細胞内動態および機能解析（2007-10） [J-GLOBAL]
• FRET型プローブを用いた哺乳類卵細胞内IP3濃度変化の測定（2006-07） [J-GLOBAL]
• マウス胚初期発生におけるホスホリパーゼCゼーターの核移行（2005-10）
• 卵活性化精子因子候補PLC‐ζのマウスはい初期発生における核移行能の解析（2005-05） [J-GLOBAL] [Othres link]
• 多変量解析的手法による蛍光スペクトル成分分離法とその細胞生理学的実験への応用（2004）
• 精子ー卵相互作用のシグナル伝達メカニズム（1994） [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link]
• 共焦点レーザー顕微鏡 その原理と応用（1994）
• ESSENTIAL ROLE OF THE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR/CA2+ RELEASE CHANNEL IN CA2+ WAVES AND CA2+ OSCILLATIONS AT FERTILIZATION OF MAMMALIAN EGGS（1993-07） [Web of Scientce]

Presentations

• Reorganization of cortical actin cytoskeleton around fertilizing sperm in mammalian eggs（2025-03-17）
• Calcium-induced reorganization of cortical actin cytoskeleton in mammalian oocytes at fertilization（2024-03-30）
• In vivo mitochondrial Ca²⁺ dynamics during tetanic muscle contraction in male and female mice（2023-03-16）
• Regulation of cortical actin dynamics and cytoplasmic flow by intracellular Ca²⁺ in mouse oocytes（2023-03-15）
• In vivo環境下における筋収縮負荷時のマウスミトコンドリア内Ca²⁺動態の可視化（2022-09-21）
• The organization and dynamics of cortical actin cytoskeleton regulated by cytosolic Ca²⁺ in mammalian eggs.（2022-03-16）
• The organization and dynamics of cortical actin cytoskeleton regulated by cytosolic Ca²⁺ in mammalian eggs.resumption in mammalian eggs（2022-03-16）
• 伸張性収縮後の筋細胞内カルシウムイオン時空間変化と根損傷の関係（2021-09-17）
• Repetitive Ca²⁺ increases coordinate the reorganization of cortical actin cytoskeleton and meiotic resumption in mammalian eggs（2021-03-30）
• Luminal Ca²⁺ dynamics in the endoplasmic reticulum during Ca²⁺ oscillations in mouse eggs analyzed using a fluorescent probe with improved subcellular localization（2021-03-28）
• 運動誘発性の損傷骨格筋に特徴的な細胞内カルシウムイオン変動パターン（2020-09-24）
• Differential regulation of cortical actin cytoskeleton by intracellular calcium in mouse eggs（2020-03-18）
• Improvement of genetically encoded probe to measure Ca²⁺ dynamics in subcellular compartments（2019-03-30）
• Calcium-dependent regulation of cortical actin filaments in mouse eggs（2019-03-29）
• 損傷再生過程における細胞内カルシウムイオンダイナミクスとmTOR系の変化（2018-09）
• Manipulating intracellular concentration of inositol trisphosphate by photoactivatable enzymes（2018-03-28）
• Dynamic reconstruction of Golgi apparatus during mammalian oocyte maturation（2018-03-28）
• Role of luminal Ca²⁺ binding proteins in the pattern formation of Ca²⁺ oscillations in mammalian eggs（2017-03-30）
• Functional requirements of interdomain interactions for the enzymatic activity of PLCzeta（2016-11-18）
• Calcium oscillation-dependent dynamics of cortical actin filaments in mouse eggs（2016-11-18）
• Mechanism for the generation of fast and slow Ca²⁺ oscillations in mouse eggs（2015-06-17）
• Measurement and analysis of changes in the ER Ca²⁺ concentration during Ca²⁺ oscillations in mouse eggs（2015-06-17）
• Mechanism for the generation of fast and slow Ca²⁺ oscillations in mouse eggs.（2015-06-17）
• Measurement and analysis of changes in the ER Ca²⁺ concentrations during Ca²⁺ oscillations in mouse eggs.（2015-06-17）
• Analysis of interdomain interactions in PLCzeta by the combined expression of split mutants（2015-03-21）
• Analysis of changes in the Ca²⁺ concentration in the endoplasmic reticulum during Ca²⁺ oscillations in mammalian eggs（2015-03-21）
• Analysis of biphasic Ca²⁺ uptake by the endoplasmic reticulum during Ca²⁺ oscillations in mouse eggs（2014-03-18）
• Numerical simulation of fast and slow Ca²⁺ oscillations in fertilized mouse eggs.（2014-03-18）
• Measurement of Ca²⁺ in the endoplasmic reticulum during Ca²⁺ oscillations in mammalian eggs.（2013-03）
• On the role of STIM/Orai pathway in Ca²⁺ entry during Ca²⁺ oscillations in fertilized mouse eggs.（2012-03）
• Visualization of intracellular IP₄ dynamics using a novel fluorescent probe（2012-03）
• On the functional role of STIM/Orai proteins in the regulation of intracellular Ca²⁺ in mouse eggs.（2011-03）
• Time-lapse observation of cytoplasmic actin filament in mouse eggs during fertilization.（2011-03）
• Pharmacological characterization of store-operated Ca²⁺ entry in mouse eggs.（2011-03）
• ユートロフィンを用いたマウス卵受精時の細胞内F-アクチンの経時的観察および解析（2011）
• 細胞内イノシトール四リン酸動態可視化のための蛍光プローブの開発（2011）
• バイオサイエンスにおける光技術の応用（2010-08）
• Evaluation and application of novel method for expression of extrinsic proteins in mouse oocytes using RNA with oligo(A) repeats.（2010）
• マウス受精卵におけるCa²⁺オシレーション発生時のCa²⁺流入の解析（2009-09）
• マウス卵におけるSTIM/Oraiタンパク質による細胞内Ca²⁺濃度調節（2009-09）
• 哺乳類受精時の細胞内Ca²⁺振動の発生・維持に対するミトコンドリアの関与（2009-09）
• 哺乳類受精時のCa²⁺反応におけるCa²⁺流入の機能的な関与の検証（2008）
• Pharmacological characterization of Ca²⁺ entry pathway during Ca²⁺ oscillations in fertilized mouse eggs.（2008）
• 非翻訳領域を付加したRNAを用いたマウス卵での外来タンパク質発現方法の検討（2007）
• Analysis of IP₃ dynamics during the intracellular Ca²⁺ oscillations in mammalina eggs.（2006）
• Physiological applications of blind spectral unmixing method based on EEM fluorescence imaging and multivariate analysis（2005）
• The role of EF-hand domains in the enzymatic activity and calcium oscillation-inducing activity of phospholipase C-zeta（2005）
• Nuclear translocation of phospholipase C-zeta during embryonic development of the mouse（2005）
• Application of blind spectral decomposition method to the measurement of membrane potential with voltage-sensitive dyes（2004）
• Phospholipase C-zeta has the ability of Ca²⁺ oscillation induction and nuclear translocation in mouse eggs（2004）
• フォスフォリパーゼＣゼータの特性とCa²⁺オシレーション誘発（2004）
• 多変量解析的手法による蛍光スペクトル分離法の細胞生物学的実験への応用（2004）
• Multicomponent measurement based on wide-range two-dimensional fluorescence microspectroscopy（2003）
• 広波長域２次元蛍光スペクトル顕微測光に基づく卵細胞内因子の多成分同時解析（2003）
• ２次元蛍光スペクトル顕微測光による細胞内多因子同時測定（2003）
• Ca²⁺/Mn²⁺ dynamics during Ca²⁺ oscillations in mouse eggs（2001）
• Dual emission ratiometric measurement of intracellular calcium with visible-light excitation（2001）
• Novel GFP-based ratiometric indicators for monitoring intracelluar pH（2001）
• GFPを利用した定量的pHプローブの開発と応用（2001）
• Optical measurement of endoplasmic reticulum membrane potential during Ca²⁺ release（2000）
• IP₃誘発性Ca遊離に伴う小胞体膜電位変化（2000）
• 精子抽出物顕微注入によるCa²⁺振動時のマウス卵のCa²⁺/Mn²⁺ダイナミクス（2000）
• マウス卵のCa²⁺ oscillationにおけるCa²⁺/Mn²⁺ influx/release（2000）
• 精子因子によるCa²⁺オシレーションと卵活性化（1999）
• Spatiotemporal analysis of intracellular calcium increases in hamster sperm induced by solubilized zona pellucida（1997）
• 哺乳類精子先体反応におけるカルシウム動態の解析（1997）
• The use of an agonist of inositol 1,4,5-trisphosphate receptor, adenophostin, for activation of mouse eggs injected with round spermatids（1997）
• 円形精子細胞注入マウス卵の活性化法：非分解性IP₃アナログの利用（1997）
• マウスICSI卵におけるカルシウム画像解析（1996）
• Changes in the distribution of the endoplasmic reticulum and inositol 1,4,5-trisphosphate receptors during meiotic maturation of hamster oocytes（1995）
• Spatiotemporal analysis of the increases of nuclear and cytoplasmic Ca²⁺ induced by IP₃ in hamster oocytes.（1995）
• ハムスター未成熟卵核でのCa²⁺動態の解析（1995）
• マウス卵細胞室内精子注入法における卵細胞内カルシウムイオン画像解析（1995）
• Analysis of Ca²⁺ wave in hamster eggs using confocal microscopy（1994）
• 卵細胞内Ca²⁺の画像解析と共焦点レーザー顕微鏡（1994）
• Activation of calcium influx pathway by inositol 1,3,4,5-tetrakisphosphate in hamster eggs（1993）
• Increase in sensitivity of the inositol trisphosphate receptor during maturation of hamster oocytes（1993）
• Monoclonal antibody to inositol 1,4,5-trisphosphate receptor blocks Ca²⁺ wave and Ca²⁺ oscillation in fertilized hamster eggs（1992）
• ハムスター卵受精時のCa waveおよびCa oscillationsはIP₃依存性Ca遊離に基づく（1992）
• 受精現象におけるIP₃レセプターの役割（1992）
• ハムスター卵受精時の細胞内カルシウムイオン遊離機構（1992）

Books and Other Publications

• 細胞内カルシウム実験プロトコール（1996）
• 電子顕微鏡基礎技術と応用～物質のナノ局在解析～（1994）
• Biology of Germ Lines in Animals and Man（1993）

Works

Research Projects

Media Coverage

Industrial Property Rights

Professional Memberships

• 日本生理学会
• 日本発生生物学会
• 日本生物物理学会
• Biophysical Society（アメリカ）
• 日本動物学会

Committee Memberships

Teaching Experience

Social Contribution

Academic Contribution