Degree

Research History

Education

Awards

• 日本微小循環学会奨励賞 優秀賞（2013-02）
• The Melvin H. Knisely Award（2008-08）

Others

Papers

• Optical Imaging of Microvascular Function in the Brain（2025-07） [DOI] [Othres link]
• Ring-Shaped Microparticle Autonomously Anchored in Microchannel for Intravascular Implantable Devices（2025-06-29） [DOI] [Othres link]
• A non-invasive approach to monitoring microcirculatory health before and after hemodialysis in renal patients using nailfold video capillaroscopy with optical reflectance analysis（2025-05-17） [DOI] [Othres link] [Othres link]
• Cyclin-dependent kinase inhibitor p18 regulates lineage transitions of excitatory neurons, astrocytes, and interneurons in the mouse cortex（2024-12-12） [DOI] [Othres link] [Othres link]
• Microfluctuations in Capillary Lumens Independent of Pericyte Lining Density in the Anesthetized Mouse Cortex（2024-09-16） [DOI] [Othres link]
• Effect of Diabetes on Microvascular Morphology and Permeability of Rat Skeletal Muscle: In Vivo Imaging Using Two-Photon Laser Scanning Microscopy（2024-08-15） [DOI] [Othres link]
• Serotonergic regulation of cortical neurovascular coupling and hemodynamics upon awakening from sleep in mice（2024-03-13） [DOI] [Othres link] [Othres link]
• Detection of backside coupled propagating surface plasmon resonance on the sidewall of a wafer（2023-11-01） [DOI] [Othres link]
• Acceleration of the Development of Microcirculation Embolism in the Brain due to Capillary Narrowing（2023-08） [DOI] [PubMed] [Othres link]
• Capillary responses to functional and pathological activations rely on the capillary states at rest（2023-02-08） [DOI] [PubMed] [PubMed Central] [Othres link] [Othres link]
• Close association between spreading depolarization and development of infarction under experimental ischemia in anesthetized male mice（2022-10） [DOI]
• Spatiotemporal analysis of blood plasma and blood cell flow fluctuations of cerebral microcirculation in anesthetized rats（2022-09-22） [DOI] [Othres link] [Othres link]
• Automated capillary flow segmentation and mapping for nailfold video capillaroscopy（2022-03） [DOI] [Othres link] [Othres link]
• 実験動物の画像情報に基づいた行動評価法の提案:撮像のフレームレートによる影響評価（2021-12）
• Three-dimensional microvascular network reconstruction from in vivo images with adaptation of the regional inhomogeneity in the signal-to-noise ratio（2021-07-01） [DOI] [PubMed]
• Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice（2021-07） [DOI]
• Vascular permeability of skeletal muscle microvessels in rat arterial ligation model: in vivo analysis using two-photon laser scanning microscopy.（2021-06-01） [DOI] [PubMed]
• Error Evaluation for Automated Diameter Measurements of Cerebral Capillaries Captured with Two-Photon Laser Scanning Fluorescence Microscopy（2021-05-09） [DOI] [Othres link]
• Time Series Tracking of Cerebral Microvascular Adaptation to Hypoxia and Hyperoxia Imaged with Repeated In Vivo Two-Photon Microscopy（2021-05-09） [DOI] [Othres link]
• Differential pial and penetrating arterial responses examined by optogenetic activation of astrocytes and neurons（2021-04-25） [DOI] [PubMed] [PubMed Central] [Othres link] [Othres link]
• Mapping of flow velocity using spatiotemporal changes in time‐intensity curves from indocyanine green videoangiography（2021-03-03） [DOI] [Othres link] [Othres link]
• Tracking tau fibrillogenesis and consequent primary phagocytosis of neurons mediated by microglia in a living tauopathy model（2020-11-05） [DOI] [Othres link]
• Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states（2020-09-07） [DOI] [PubMed] [PubMed Central] [Othres link] [Othres link]
• Neurosurgical intraoperative ultrasonography using contrast enhanced superb microvascular imaging -vessel density and appearance time of the contrast agent-（2020-07-10） [DOI] [PubMed] [Othres link]
• Spatiotemporal dynamics of red blood cells in capillaries in layer I of the cerebral cortex and changes in arterial diameter during cortical spreading depression and response to hypercapnia in anesthetized mice（2019-06-02） [DOI] [PubMed] [Othres link] [Othres link]
• Vascular Gap Junctions Contribute to Forepaw Stimulation-Induced Vasodilation Differentially in the Pial and Penetrating Arteries in Isoflurane-Anesthetized Rats（2018-12-03） [DOI] [PubMed] [PubMed Central] [Othres link]
• Optical imaging and modulation of neurovascular responses.（2018-12） [DOI]
• Microvascular permeability of skeletal muscle after eccentric contraction-induced muscle injury: in vivo imaging using two-photon laser scanning microscopy（2018-08-01） [DOI] [PubMed] [Othres link]
• Positron emission tomography of cerebral angiogenesis and TSPO expression in a mouse model of chronic hypoxia（2018-04-01） [DOI] [PubMed]
• Changes in effective diffusivity for oxygen during neural activation and deactivation estimated from capillary diameter measured by two-photon laser microscope（2017-03） [DOI] [PubMed] [Web of Scientce]
• Dynamic diameter response of intraparenchymal penetrating arteries during cortical spreading depression and elimination of vasoreactivity to hypercapnia in anesthetized mice（2017-02） [DOI] [PubMed] [Web of Scientce]
• Long-term repeated in vivo real-time analysis of microglia in the mouse cortex with a closed-cranial window by Tomita-Seylaz method（2017） [DOI] [CiNii Research (CiNii Articles)] [Othres link]
• Dynamic Flow Velocity Mapping from Fluorescent Dye Transit Times in the Brain Surface Microcirculation of Anesthetized Rats and Mice（2016-08） [DOI] [PubMed] [Web of Scientce]
• ASTROCYTIC DEPOLARIZATION INDUCED RAPID AND BROAD INCREASE IN CBF IN IN VIVO MOUSE CORTEX（2016-06） [Web of Scientce]
• BEHAVIOR OF RED BLOOD CELLS IN INTRAPARENCHYMAL CAPILLARIES DURING CORTICAL SPREADING DEPRESSION OBSERVED WITH HIGH-SPEED CAMERA CONFOCAL FLUORESCENCE MICROSCOPE IN ANESTHETIZED MICE（2016-06） [Web of Scientce]
• Long-term effects of cerebral hypoperfusion on neural density and function using misery perfusion animal model（2016-04） [DOI] [PubMed] [Web of Scientce]
• Establishment and evaluation of a new highly metastatic tumor cell line 5a-D-Luc-ZsGreen expressing both luciferase and green fluorescent protein（2016-02） [DOI] [PubMed] [Web of Scientce]
• Fluorescence Imaging of Blood Flow Velocity in the Rodent Brain（2016） [DOI] [PubMed] [Web of Scientce]
• Unveiling astrocytic control of cerebral blood flow with optogenetics（2015-06） [DOI] [PubMed] [Web of Scientce]
• Hyperperfusion counteracted by transient rapid vasoconstriction followed by long-lasting oligemia induced by cortical spreading depression in anesthetized mice（2015-03-31） [PubMed] [DOI]
• Pial arteries respond earlier than penetrating arterioles to neural activation in the somatosensory cortex in awake mice exposed to chronic hypoxia: an additional mechanism to proximal integration signaling?（2014-11） [DOI] [Web of Scientce]
• Changes in cortical microvasculature during misery perfusion measured by two-photon laser scanning microscopy（2014-08） [DOI] [Web of Scientce]
• Cerebral hemodynamic response to acute hyperoxia in awake mice（2014-04） [DOI] [Web of Scientce]
• Vessel Specific Imaging of Glucose Transfer with Fluorescent Glucose Analogue in Anesthetized Mouse Cortex（2014-03-22） [DOI] [PubMed] [Othres link]
• Automated Image Analysis for Diameters and Branching Points of Cerebral Penetrating Arteries and Veins Captured with Two-Photon Microscopy（2014-03-22） [DOI] [PubMed] [Web of Scientce] [Othres link]
• Microvascular sprouting, extension, and creation of new capillary connections with adaptation of the neighboring astrocytes in adult mouse cortex under chronic hypoxia（2014-02） [DOI] [Web of Scientce]
• Reproducibility of measuring cerebral blood flow by laser-Doppler flowmetry in mice（2014） [DOI] [PubMed]
• Hemodynamic changes during neural deactivation in awake mice: A measurement by laser-Doppler flowmetry in crossed cerebellar diaschisis（2013-11） [DOI]
• Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls（2013-09） [DOI] [Web of Scientce]
• Layer-specific dilation of penetrating arteries induced by stimulation of the nucleus basalis of Meynert in the mouse frontal cortex（2013-09） [DOI] [PubMed]
• Hypoxia-Induced Cerebral Angiogenesis in Mouse Cortex with Two-Photon Microscopy（2013-06-04） [DOI] [Web of Scientce] [Othres link]
• Measuring the Vascular Diameter of Brain Surface and Parenchymal Arteries in Awake Mouse（2013-06-04） [DOI] [PubMed] [Othres link]
• Long-term adaptation of cerebral hemodynamic response to somatosensory stimulation during chronic hypoxia in awake mice（2013-05） [DOI] [PubMed] [Scopus] [Scopus]
• Phantom and mouse experiments of time-domain fluorescence tomography using total light approach（2013-04） [DOI] [Web of Scientce]
• Potassium-induced cortical spreading depression bilaterally suppresses the electroencephalogram but only ipsilaterally affects red blood cell velocity in intraparenchymal capillaries（2013-04） [DOI] [Web of Scientce]
• Three-dimensional cortex model including vascular structure for estimation of path length for optical imaging（2013）
• Image-based vessel-by-vessel analysis for red blood cell and plasma dynamics with automatic segmentation（2012-09） [DOI] [Web of Scientce]
• Long-term effects of hepatocyte growth factor gene therapy in rat myocardial infarct model（2012-08） [DOI] [Web of Scientce]
• Dynamic Two-Photon Imaging of Cerebral Microcirculation Using Fluorescently Labeled Red Blood Cells and Plasma（2012-07-21） [DOI] [Web of Scientce] [Othres link]
• 3D Analysis of Intracortical Microvasculature During Chronic Hypoxia in Mouse Brains（2012-07-21） [DOI] [Web of Scientce] [Othres link]
• Anesthesia and the quantitative evaluation of neurovascular coupling（2012-07） [DOI] [Web of Scientce]
• Repeated Longitudinal in Vivo Imaging of Neuro-glio-vascular Unit at the Peripheral Boundary of Ischemia in Mouse Cerebral Cortex（2012-06-14） [DOI] [PubMed]
• Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice（2012-03） [DOI] [Web of Scientce]
• Spatial Frequency-Based Analysis of Mean Red Blood Cell Speed in Single Microvessels: Investigation of Microvascular Perfusion in Rat Cerebral Cortex（2011-08） [DOI] [Web of Scientce]
• Comparison of Temporal Response to Cerebral Blood Flow Measured by Laser Speckle Flowgraphy and Laser Doppler Flowmetry（2011） [DOI]
• Reproducibility and variance of a stimulation-induced hemodynamic response in barrel cortex of awake behaving mice（2011-01） [DOI] [Web of Scientce]
• Frequency-dependent neural activity, CBF, and BOLD fMRI to somatosensory stimuli in isoflurane-anesthetized rats（2010-08） [DOI] [Web of Scientce]
• Cerebrovascular dynamics in response to neural stimulation（2010-07-08） [Scopus] [Scopus]
• Changes in cerebral arterial, tissue and venous oxygenation with evoked neural stimulation: implications for hemoglobin-based functional neuroimaging（2010-02） [DOI] [Web of Scientce]
• Cerebral oxygen delivery and consumption during evoked neural activity（2010） [DOI]
• Intracortical Microcirculatory Change Induced by Anesthesia in Rat Somatosensory Cortex（2009-10-24） [DOI] [Web of Scientce] [Othres link]
• Dose‐dependent effect of isoflurane on neurovascular coupling in rat cerebral cortex（2009-07-20） [DOI] [Web of Scientce] [Othres link]
• Brain Tissue Oxygen Consumption And Supply Induced By Neural Activation:（2009） [DOI] [Web of Scientce] [Othres link]
• Neurovascular coupling in primary auditory cortex investigated with voltage-sensitive dye imaging and laser-Doppler flowmetry（2008-12） [DOI] [Web of Scientce]
• Dynamics of oxygen delivery and consumption during stimulation using a compartment model and CBF and tissue P-O2 measurements（2008-08） [DOI] [Web of Scientce]
• Multimodal Silica-Shelled Quantum Dots: Direct Intracellular Delivery, Photosensitization, Toxic, and Microcirculation Effects（2008-05-22） [DOI] [Othres link]
• Trial-by-trial relationship between neural activity, oxygen consumption, and blood flow responses（2008-04） [DOI] [Web of Scientce]
• Imaging brain vasculature with BOLD microscopy: MR detection limits determined by in vivo two-photon microscopy（2008-04） [DOI] [Web of Scientce]
• Apparent diffusion time of oxygen from blood to tissue in rat cerebral cortex: implication for tissue oxygen dynamics during brain functions（2007-10） [DOI] [Web of Scientce] [Othres link]
• Arterial versus Total Blood Volume Changes during Neural Activity-Induced Cerebral Blood Flow Change: Implication for BOLD fMRI（2006-12-20） [DOI] [Web of Scientce] [Othres link] [Othres link]
• Relationship between Neural, Vascular, and BOLD Signals in Isoflurane-Anesthetized Rat Somatosensory Cortex（2006-05-17） [DOI] [Web of Scientce] [Othres link]
• Successive depth variations in microvascular distribution of rat somatosensory cortex（2004-01） [DOI] [Web of Scientce]
• Biphasic Changes in Tissue Partial Pressure of Oxygen Closely Related to Localized Neural Activity in Guinea Pig Auditory Cortex（2003-09） [DOI] [Web of Scientce] [Othres link] [Othres link]
• Dual responses of tissue partial pressure of oxygen after functional stimulation in rat somatosensory cortex（2003-07） [DOI] [Web of Scientce]

Misc

• in vivoマウス大脳微小血管の４Dイメージング（2019-06-10）
• 光イメージングによる脳卒中の研究（2018-08-01）
• アストロサイトによる脳血流調節（2016-01） [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link]
• In vivo optical imaging of structural and functional plasticity of neurovascular unit（2015） [DOI] [Othres link]
• 光遺伝学による脳血流の操作（2014-11-07） [J-GLOBAL]
• 脳表血管・細胞光イメージング（2014-07）
• Hypoxia-induced adaptation of cerebral microvasculature.（2014-02）
• ニューロサイエンスの最新情報 二光子顕微鏡法による脳の微小循環の測定・観察（2013-11）
• 前脳基底部の刺激で誘発される大脳皮質の層特異的な血管拡張反応（2013-08-31）
• 脳賦活および脳機能抑制による局所脳有効酸素拡散能の変化ー毛細血管径の変化からの推定ー（2013-07-31）
• マイネルト核刺激による大脳皮質層特異的な動脈拡張反応（2013-05-12） [J-GLOBAL]
• Microscopic Optical Imaging of Neurovascular Coupling（2012-12-07） [CiNii Research (CiNii Articles)] [CiNii Books]
• 脳虚血・低酸素モデルマウスにおける血管新生ライブイメージング（2012-09）
• In Vivo imaging of neurovascular coupling with two-photon excitation laser scanning microscopy（2012-04）
• 脳機能賦活に起因するマウス皮質組織血流のレーザー計測（2012-04）
• 脳微小血管と４Ｄイメージング（2012）
• 生物発光・蛍光と生体イメージング（2011） [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link]
• 生体二光子顕微鏡による脳内微小循環径路の三次元追跡（2011）
• 光で探る神経血管カップリング（2010）
• Neurovascular coupling and its molecular mechanism（2008-02-08） [CiNii Research (CiNii Articles)] [CiNii Books]
• Oxygen transport in the microvessel network（2005） [Web of Scientce]

Presentations

• 微小循環: 最も細い血管を見て知る体の健康（2024-10-26）
• Capillary flow imbalances under dehydration in the brain.（2024-09-07）
• 脳における赤血球動態の解析（2024-05-11）
• 認知学習実験における温度環境の影響（2022） [Othres link]

Books and Other Publications

• 最新臨床脳卒中学（第２版）下ー最新の診断と治療ー（2022-02-28）
• 実験医学増刊 脳の半分を占めるグリア細胞 脳と心と体をつなぐ”膠”（2019-11-01）
• 血流改善成分の開発と応用（2018-07-30）
• 脳卒中病態学のススメ（2018-02）
• Vascular remodeling after cerebral ischemia. (In: Primer on Cerebrovascular Diseases, Second Edition)（2017-03-18）
• New Horizons in Neurovascular Coupling : A Bridge between Brain Circulation and Neural Plasticity（2016-04）
• Bridging macroscopic and microscopic methods for the measurements of cerebral blood flow: Toward finding the determinants in maintaining the CBF homeostasis（2016） [DOI]
• ユニーク&エキサイティングサイエンスIII (総合コミュニケーション科学シリーズ)（2014-11-26）
• シミュレーション辞典（2012-02-27）
• からだと酸素の事典（2009-09-05）
• CBF and pO2 dynamics in rat cortex during neuronal activation by hind paw stimulation（2004）

Works

Research Projects

Media Coverage

Industrial Property Rights

Professional Memberships

• 一般社団法人 日本機械学会

Committee Memberships

Teaching Experience

Social Contribution

Academic Contribution