Degree

• 理学博士（大阪大学）
• Ph.D（Osaka University）

Research History

Education

Awards

• Outstanding Reviewer（2018-08）
• 日本神経科学学会奨励賞（2008）

Others

Papers

• Selective Lower‐Occupied Through‐Bond Interactions for Efficient Organic Phosphorescence Enabling High‐Resolution Long‐Wavelength Afterglow（2025-04-24） [DOI] [Othres link]
• SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons.（2025-01） [DOI] [PubMed] [ResearchMap]
• Activation of innate immune receptor TLR9 by mitochondrial DNA plays essential roles in the chemical long-term depression of hippocampal neurons（2024-03） [DOI] [ResearchMap]
• Subunit-dependent and subunit-independent rules of AMPA receptor trafficking during chemical long-term depression in hippocampal neurons（2021-07-10）
• PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover（2019-03-13）
• PhotonSABER: new tool shedding light on endocytosis and learning mechanisms in vivo.（2019） [DOI] [PubMed] [PubMed Central]
• エンドサイトーシスを制御する新しい技術により明らかにされた小脳における長期抑圧と運動学習との因果関係（2018-09-10） [DOI]
• Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning.（2018-09-05） [DOI] [PubMed]
• Chemical labelling for visualizing native AMPA receptors in live neurons（2017-04） [DOI] [Web of Scientce]
• AP-4（2016） [DOI]
• Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis（2014-01） [DOI] [Web of Scientce]
• Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression（2013-11） [DOI] [Web of Scientce]
• The delta 2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites（2013-03） [DOI] [Web of Scientce]
• NMDA Receptor-Mediated PIP5K Activation to Produce PI(4,5)P-2 Is Essential for AMPA Receptor Endocytosis during LTD（2012-01） [DOI] [Web of Scientce]
• D-Serine regulates cerebellar LTD and motor coordination through the delta 2 glutamate receptor（2011-05） [DOI] [Web of Scientce]
• Cerebellar long-term depression requires dephosphorylation of TARP in Purkinje cells.（2011）
• 小脳長期抑制とTARPによる制御(Cerebellar LTD and regulation by TARPs)（2010-08）
• 細胞内輸送と代謝 AP-4欠損神経細胞軸索におけるAMPA受容体のオートファゴソームへの集積（2009-03）
• Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum（2009-02） [DOI] [Web of Scientce]
• Polarized sorting of AMPA receptors to the somatodendritic domain is regulated by adaptor protein AP-4.（2009）
• AP-4: Autophagy-four mislocalized proteins in axons（2008-08-16） [DOI] [PubMed]
• Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4（2008-03） [DOI] [Web of Scientce]
• Mechanisms for polarized sorting of glutamate receptors to the somatodendritic domain of neurons（2008） [Web of Scientce]
• The extreme C-terminus of GluR delta 2 is essential for induction of long-term depression in cerebellar slices（2007-03） [DOI] [Web of Scientce]
• Characterization of the delta 2 glutamate receptor-binding protein delphilin - Splicing variants with differential palmitoylation and an additional PDZ domain（2006-09） [DOI] [Web of Scientce]
• A new motif necessary and sufficient for stable localization of the delta 2 glutamate receptors at postsynaptic spines（2006-06） [DOI] [Web of Scientce]
• Roles of the N-terminal domain on the function and quaternary structure of the ionotropic glutamate receptor（2005-05） [DOI] [Web of Scientce]
• Rescue of abnormal phenotypes of the delta 2 glutamate receptor-null mice by mutant delta 2 transgenes（2005-01） [DOI] [Web of Scientce]
• The C-terminal juxtamembrane region of the delta 2 glutamate receptor controls its export from the endoplasmic reticulum（2004-04） [DOI] [Web of Scientce]
• A hot spot for hotfoot mutations in the gene encoding the delta 2 glutamate receptor（2003-04） [DOI] [Web of Scientce]
• Heteromer formation of delta 2 glutamate receptors with AMPA or kainate receptors（2003-01） [Web of Scientce]
• Mutation in hotfoot-4J mice results in retention of delta 2 glutamate receptors in ER（2002-10） [DOI] [Web of Scientce]
• Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability.（2002） [CiNii Research (CiNii Articles)]
• Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons（2000-06） [Web of Scientce]
• Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein（1999-10） [Web of Scientce]
• Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells（1999-09） [Web of Scientce]
• The clustering of NMDA receptor NR1 subunit is regulated by the interaction between the C-terminal exon cassettes and the cytoskeleton（1999-08） [Web of Scientce]
• Role of carboxyl-terminal charges on S-modulin membrane affinity and inhibition of rhodopsin phosphorylation（1999-01） [Web of Scientce]
• Evolution of visual pigments and related molecules（1999） [PubMed]
• The role of calcium-binding sites in S-modulin function（1998-08） [Web of Scientce]
• A novel subtype of G-protein-coupled receptor kinase, GRK7, in teleost cone photoreceptors（1998-03） [Web of Scientce]
• Functional expression and characterization of frog photoreceptor-specific calcium-binding proteins（1997-05） [Web of Scientce]
• Photoreceptor protein s26, a cone homologue of S-modulin in frog retina（1996-08） [Web of Scientce]

Misc

• Chemical LTD stimulation induced the drastic mitochondrial morphological changes in cultured hippocampal neurons（2023-03） [ResearchMap]
• Mechanism of hippocampal adult-born neurons for memory consolidation（2022-12） [DOI]
• 【小脳学習説Marr-Albus-Ito理論の50年】小脳学習における長期抑圧(LTD)の役割（2019-08）
• Optogenetic control of the function of the Golgi apparatus in neurons（2014-11） [Web of Scientce]
• Stargazin regulates AMPA receptor trafficking from plasma membrane to early endosome and lysosome during long term depression（2013） [Web of Scientce]
• How does the delta 2 glutamate receptor regulate cerebellar LTD?（2013） [Web of Scientce]
• Cerebellar LTD and regulation by TARPs（2010） [DOI] [Web of Scientce]
• New mechanisms regulating stability and dynamics of AMPA receptors（2010） [DOI] [Web of Scientce]
• New mechanisms regulating the number of AMPA receptors at synapses（2009） [DOI] [Web of Scientce]
• How polarized sorting to neuronal dendrites is achieved: a newly discovered AP4-based system（2008-12） [CiNii Research (CiNii Articles)]
• Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons (vol 19, pg 2765, 2000)（2003-01） [Web of Scientce]
• Phosphorylation of serine 880 in GluR2 by protein kinase C prevents its C-terminus binding with the glutamate receptor interacting protein, GR（2000） [Web of Scientce]

Presentations

• Chemical LTD stimulation induces an increase in mitochondrial Ca2+ concentration, which is important for mitochondrial morphological changes（2025-03-19）
• リソソーム開口放出に着目した光遺伝学による長期可塑性の新規制御ツール（2023-08-03） [ResearchMap]
• Chemical LTD stimulation induced the drastic mitochondrial morphological changes in cultured hippocampal neurons（2023-03-15）
• シナプス可塑性の光操作－記憶・学習を制御するオプトジェネティクス－（2020-12-03）
• シナプス可塑性の光操作－記憶・学習を制御するオプトジェネティクス－（2020-12-03）
• Lysosomal exocytosis controls AMPA receptor trafficking（2020-07）
• MMP-9 activity is required for the NMDA induced endocytosis of AMPA receptor（2019-03-29）
• New optogenetical tool clarified that the cerebellar LTD was essential for motor learning（2019-03-29）
• Lysosomal exocytosis is essential for NMDA-induced AMPA receptor exocytosis and LTP in hippocampus（2019-02-10）
• Optogenetical control of AMPA receptor endocytosis clarified that the cerebellar long term depression directly regulate motor learning（2018-03-05）
• Development of the optogennetical technique which control the endocytosis of AMPA receptor and the long-term depression（2017-07-21）
• Analysis of the relationship between cerebellar LTD and motor learning by novel optogenetical tool（2017-03-30）
• Novel optogenetical technique clarified that the cerebellar LTD was essential for the motor learning（2016-11-17）
• The interaction between stargazin and synaptotagmin-7 is controlled by both of phosphorylation and Ca2+ concentration.（2016-07-21）
• Intracellular trafficking of AMPA receptor-TARP complex（2016-03-23）
• Understanding and controlling synaptic plasticity（2015-08-01）
• Molecular mechanism and controlling method for synaptic plasticity（2015-07-30）
• シナプス可塑性を支えるAMPA受容体の細胞内輸送機構（2014-09-29）
• Development of the technology for controlling synaptic plasticity（2013）
• Stargazin regulates AMPA receptor trafficking from plasma membrane to early endosome and lysosome during long term depression.（2013）
• AMPA受容体のエンドサイトーシス制御機構（2012-06-14）
• New mechanisms regulating the number of AMPA receptors at synapses（2009）
• AP-4によるAMPA受容体の極性輸送（2008-11-22）
• Mechanisms for polarized sorting of glutamate receptors to the somatodendritic domain of neurons（2008）
• Mechanisms for Polarized Sorting of Glutamate Receptors to the Somatodendritic Domain of Neurons（2007）

Books and Other Publications

• CLINICAL NEUROSCIENCE 小脳学習説 Marr-Albus-Ito理論の50年（2019）
• 脳科学辞典（アダプタータンパク質複合体）（2018-11-17）
• Principles of Neurobiology（2017-08-08）
• 脳科学辞典（長期抑圧）（2015-09-17）
• 蛋白質核酸酵素増刊 「メンブレントラフィックの奔流」（2008-12）

Works

Research Projects

Media Coverage

Industrial Property Rights

Professional Memberships

• 日本小脳学会
• Society for Neuroscience
• The Japan Neuroscience Society
• Physiological society of Japan

Committee Memberships

Teaching Experience

• 基盤理工学専攻基礎
• 基盤理工学専攻基礎
• 化学生命工学実験第二
• 化学生命工学実験第二
• UECパスポートセミナー
• UECパスポートセミナー
• 生体情報システム論１
• 生体情報システム論１
• 先進理工学基礎
• 生体機能システム実験第二
• 先進理工学基礎
• 先進理工学基礎
• 生体機能システム実験第二
• 生体機能システム実験第二
• Biology
• Molecular Biology
• 分子生物学
• neurosience
• 神経科学
• 生物学
• 生物学
• Fundamentals of Information Biology
• 生体情報学基礎

Social Contribution

• 夏休みは電通大でラボ体験2023
• スプリングスクール

Academic Contribution

• 第47回日本神経科学大会プログラム委員
• 博士前期課程入試面接
• 学域一般入試採点(後期試験）
• 先端工学基礎課程面接試験