学位

• 博士（理学）(電気通信大学 2018.9)

経歴

学歴

受賞

その他

論文

• Noninvasive Bioluminescence Imaging of Serum Albumins in Living Mice [DOI] [Othres link]
• Near-infrared in vivo imaging system for dynamic visualization of lung-colonizing bacteria in mouse pneumonia [DOI] [Othres link]
• Regiospecific Coelenterazine Analogs for Bioassays and Molecular Imaging [DOI] [Othres link]
• Unimolecular Chemiexcited Oxygenation of Pathogenic Amyloids [DOI] [Othres link]
• Synthesis and anti-tumor activities in human leukemia-derived cells of polyenylpyrroles with a methyl group at the conjugated polyene terminus [DOI]
• Identification of compounds that preferentially suppress the growth of T‐cell acute lymphoblastic leukemia‐derived cells [DOI] [Othres link]
• In vivo optical imaging of tumor stromal cells with hypoxia‐inducible factor activity [DOI] [Othres link]
• Creation of artificial luciferase 60s from sequential insights and their applications to bioassays [DOI] [Othres link]
• Coelenterazine indicators for the specific imaging of human and bovine serum albumins [DOI]
• Bright Molecular Strain Probe Templates for Reporting Protein–Protein Interactions [DOI] [Othres link]
• Bioluminescent imaging systems boosting near-infrared signals in mammalian cells [DOI] [Othres link] [Othres link]
• S-Series Coelenterazine-Driven Combinatorial Bioluminescence Imaging Systems for Mammalian Cells [DOI] [Othres link]
• Single-chain multicolor-reporter templates for subcellular localization of molecular events in mammalian cells [DOI] [Othres link]
• C-Series Coelenterazine-Driven Bioluminescence Signature Imaging [DOI] [Othres link]
• Multiplex quadruple bioluminescent assay system [DOI]
• Quantum Yield of Near-Infrared Bioluminescence with Firefly Luciferin Analog: AkaLumine [DOI]
• Bioluminescence imaging using d -luciferin and its analogs for visualizing Bdnf expression in living mice; different patterns of bioluminescence signals using distinct luciferase substrates [DOI] [Othres link]
• Absorption Spectra for Firefly Bioluminescence Substrate Analog: TokeOni in Various pH Solutions [DOI] [Web of Scientce] [Othres link] [Othres link]
• Development of phenyl oligoene-type firefly luciferin analogues with extended π-electronic conjugation for near-infrared bioluminescence [DOI] [Othres link]
• Synthesis of polyenylpyrrole derivatives with selective growth inhibitory activity against T-cell acute lymphoblastic leukemia cells [DOI]
• How to Select Firefly Luciferin Analogues for In Vivo Imaging [DOI] [Othres link]
• Color-tunable bioluminescence imaging portfolio for cell imaging [DOI] [Othres link] [Othres link]
• High Sensitivity In Vivo Imaging of Cancer Metastasis Using a Near-Infrared Luciferin Analogue seMpai. [DOI] [PubMed] [PubMed Central]
• Development of near-infrared firefly luciferin analogue reacted with wild-type and mutant luciferases. [DOI] [PubMed] [PubMed Central]
• Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of firefly luciferin analogues by allyl substitution [DOI] [Othres link]
• An allylated firefly luciferin analogue with luciferase specific response in living cells [DOI]
• Aspiration Risk Detection Using Oral Administration of Fluorescent Food - Preliminary Experiments Using Meat Phantoms [DOI] [DBLP] [Web of Scientce] [Othres link]
• Polymeric one- and two-dimensional copper(i) iodide complexes showing photoluminescence tunable by azaaromatic ligands [DOI]

その他業績

• 近赤外発光試薬seMpaiによるがん転移のイメージング [J-GLOBAL]
• 近赤外蛍光を用いた咽頭残留の非侵襲検出法の開発:ファントムを用いた検出能評価 [J-GLOBAL]
• 近赤外蛍光を用いた非侵襲咽頭残留検出装置のヒトにおける検出性評価 [J-GLOBAL]
• 誤嚥検査のための近赤外蛍光を用いた咽頭残留検出システムの開発 [J-GLOBAL]
• in vivo光イメージングを志向したNIRルシフェリンアナログ [J-GLOBAL]
• Innovation of new luciferin analog for in vivo optical imaging [Web of Scientce]
• ホタルルシフェリンアナログのアリル基導入による波長制御 [J-GLOBAL]
• ホタルルシフェリンアナログのアリル基導入による波長制御 [J-GLOBAL]
• 世界最長波長で発光する新規ルシフェリンアナログの創製 [J-GLOBAL]
• 世界最長波長で発光する新規ホタルルシフェリンアナログの創製 [J-GLOBAL]
• 世界最長波長で発光する新規ホタルルシフェリンアナログの創製 [J-GLOBAL]
• 世界最長波長で発光する新規ホタルルシフェリンアナログの創製 [J-GLOBAL]

講演・口頭発表等

書籍等出版物

作品等

共同研究・競争的資金等の研究課題

• 発光細胞アレイを用いた化学物質のホルモン様活性・健康リスク評価基盤の創出
• ホタル生物発光システムの大規模スクリーニング研究
• ホタル発光系における特異的発光を示す新規ルシフェリンアナログの構造活性相関研究

メディア報道

産業財産権

• 生物発光酵素の長波長発光基質
• 急性Ｔリンパ芽球性白血病若しくはリンパ腫、又は急性骨髄性白血病治療用医薬
• 新規ピロール誘導体、及びがん治療用医薬組成物
• アルブミンの検出剤
• 新規複素環式化合物及びその塩、並びに、発光基質組成物
• 新規複素環式化合物及びその塩、並びに発光基質組成物
• 新規セレンテラジン誘導体
• 発光システム及びシトクロムＰ４５０の定量方法
• 新規複素環式化合物及びその塩、並びに発光基質組成物

所属学協会

委員歴

担当経験のある科目

• 自然科学実験（化学）

社会貢献活動

学術貢献活動